Diels-Alder cycloaddition strategy for kinetic resolution of chiral pyrazolidinones.
نویسندگان
چکیده
A rare example of the application of a catalytic, enantioselective Diels-Alder cycloaddition to affect a kinetic resolution has been developed. Chiral pyrazolidinones are resolved with high selectivity through a process that utilizes a relay of stereochemical information from a permanent chiral center to a fluxional chiral center to enhance the inherent selectivity of the chiral Lewis acid catalyst.
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ورودعنوان ژورنال:
- Organic letters
دوره 11 17 شماره
صفحات -
تاریخ انتشار 2009